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Dana and Alison host a weekly podcast where they seek and give free therapy by telling you their problems, asking you to tell them your problems, and then praying to God any of it works out.

We're basically the opposite of Oprah.

Dana and Alison are not qualified and the Absolute Worst.

Dana's underwear constantly falls off of her body and Alison's vagina has atrophied...literally.

In the Absolute Worst Podcast we discuss anything you write to us about, Alison's general sluttiness, and the chaos that chases Dana around like the plague. Did I mention that we're both wives and mothers??? Everything's wrong.

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We hope you'll be able to feel better about yourselves after hearing how our lives are in shambles.

If you have a friend who's depressed, send them our podcast. The worse our lives get, the more you'll regain the willingness to live.

And maybe together we can all find the next Oprah somewhere out there...

Alison has a theory that might help you get through a tough day. It's unpleasant...

Alison and Dana talk shop and try to help a couple of people with work related questions.

Alison has a bunch of stuff wrong with her. She wants to know if you can help. You'll feel peaceful about your life after this...

This episode kicks off with a very special Absolute Yourst (these are YOUR Absolute Worst experiences) that involves Al Pacino, gluten, and an audition gone horribly wrong.

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QMUL Directory

I am interested in understanding how cancer cells ‘switch off’ the normal immune response in acute myeloid leukaemia with the aim of developing novel immunotherapeutic strategies.

I am currently developing several research projects:

I started work in the Haemato-Oncology department in the Barts Cancer Institute in October 2011 as part of John Gribben’s cancer immunotherapy group. I developed my research interests as an MRC Clinical Training Fellow in the group between 2005 and 2009 when I investigated T cells in acute myeloid leukaemia. I gained experience in immunomagnetic cell separation, flow cytometry, gene expression profiling and confocal microscopy of the immune synapse.

I developed a technique for separating T cells from the peripheral blood of patients presenting with AML that was published in the Journal of Immunological Methods in 2009 and my data characterising T cell defects in AML was published in Blood in the same year. I left Barts in 2009 to complete my clinical haematology training which included a year spent at the Hammersmith Hospital as a stem cell transplant coordinator. During this time, I gained valuable experience in the organisation as well as inpatient and outpatient management of patients undergoing allogeneic stem cell transplantation.

I now plan to develop as an independent researcher taking forward my basic science research examining T cell function in haematologic malignancy to investigate new immunotherapeutic strategies in AML.

Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts. Le Dieu R, Taussig D, Ramsay AG, Mitter R, Lee AM, Lister TA, Gribben JG. Blood 2009 Oct; 114 (18): 3909-16 PMID: nike roshe run hyperfuse challenge red

Array-based DNA methylation profiling in follicular lymphoma. O’Riain C, O’Shea DM, Yang Y, Le Dieu R, Gribben JG, Summers K, Yeboah-Afari J, Bhaw-Rosen L, Fleischmann C, Mein CA, Crook T, Smith P, Kelly G, Rosenwald A, Ott G, Campo E, Rimsza LM, Smeland EB, Chan WC, John son N, Gascoyne RD, Reimer S, Braziel RM, Wright GW, Staudt LM, Lister TA, Fitzgibbon J. Leukemia 2009 Oct; 23 (10): 1858-66 PMID: nike free 3 v4 groesse 465

Negative immunomagnetic selection of T cells from peripheral blood of presentation AML specimens. Le Dieu R, Taussig D, Lister TA, Gribben JG. Journal of Immunological Methods 2009 Aug ; 348 (1-2): 95-100 PMID: nike roshe one black pink foil sailboat

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CLEVELAND -- James Schamus makes his directing debut with "Indignation," but he's hardly a newbie in the independent film world.

As a screenwriter and producer, he has collaborated since 1992 with director Ang Lee on films as varied as "Eat Drink Man Woman," "Brokeback Mountain" and "Crouching Tiger, Hidden Dragon." As the longtime head of Focus Features, he championed the likes of Sofia Coppola, Todd Haynes and Mira Nair.

All of that experience informs his work writing and directing "Indignation," a finely calibrated, if a bit deliberate, adaptation of Philip Roth's 2008 coming-of-age novel.

It is 1951, and Marcus Messner (Logan Lerman) -- one of Roth's many literary alter egos -- is fleeing both the war in Korea and his overbearing Jewish parents in Newark, New Jersey, by heading to Ohio for college.

"Ohio?" says a neighbor, in a tone that suggests Marcus is planning to study with the pope himself at the Vatican. "How will you keep kosher?"

That's the least of Marcus's concerns once he arrives at Winesburg College (Sherwood Anderson reference intended) and discovers that he's one of just 80 Jews on a campus of 1,400, and that his presence will be required at weekly chapel for prayers and Christian teachings.

Before he leaves, his anxious father (Danny Burstein) is already in mourning, wailing, "If anything should happen to you! It's about the tiniest mistake that can happen to you!"

Which states, in blinking neon, the core theme of Roth's novel: Death is going to happen to you, like it or not, and you will make the decisions - or mistakes -- that cause it.

What mistakes does Marcus make at Winesburg? First, he falls for Olivia Hutton (Sarah Gadon), a dazzling, sexually liberated shiksa who turns out to be a deeply troubled girl. Then, he mixes it up in two extended arguments with the pompous Dean Caudwell (Tracy Letts), who admires Marcus's intellectual acumen but wants him to conform to the stultifying culture of Winesburg.

The first of these debates forms the centerpiece of "Indignation," a gambit that works far better in print than on screen. Though both actors handle the heated argument with agility and even a touch of wry humor, it's still 15 minutes of two people talking in an office, and it grows tiresome.

At a crisis point, Marcus's mother (Linda Emond) arrives from Newark on a rescue mission. In one of Roth's signature ironies, though, her meddling is that "tiniest mistake" in a chain of mistakes that lead to disaster.

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